Analysis of coronary bifurcations by intravascular ultrasound and virtual histology

Toggweiler, Stefan; Urbanek, Nadja; Schoenenberger, Andreas W; Erne, Paul (2010). Analysis of coronary bifurcations by intravascular ultrasound and virtual histology. Atherosclerosis, 212(2), pp. 524-527. Amsterdam: Elsevier 10.1016/j.atherosclerosis.2010.06.045

[img] Text
Toggweiler Atherosclerosis 2010.pdf - Published Version
Restricted to registered users only
Available under License Publisher holds Copyright.

Download (152kB) | Request a copy

Background Regional differences in shear stress have been identified as reason for early plaque formation in vessel bifurcations. We aimed to investigate regional plaque morphology and composition using intravascular ultrasound (IVUS) and virtual histology (IVUS–VH) in coronary artery bifurcations. Methods We performed IVUS and IVUS–VH studies at coronary bifurcations to analyze segmental plaque burden and composition of different segments in relation to their orientation to the bifurcation. Results A total of 236 patients with a mean age of 59 ± 11 years (69% male) were analyzed. Plaque burden was higher at the contralateral vessel wall facing the bifurcation compared to the ipsilateral vessel wall and this difference was true for proximal and distal segments (proximal: 37 ± 12% and 45 ± 15% for segments at the ipsilateral and contralateral vessel wall, respectively, p < 0.001; distal: 37 ± 10% and 47 ± 15% for segments at the ipsilateral and contralateral vessel wall, respectively, p < 0.001). In addition, these segments exhibited a higher proportion of dense calcium and a lower proportion of fibrous tissue and fibro fatty tissue. Conclusions Segments on the contralateral wall of the bifurcation which have previously been identified as regions with low shear stress not only exhibited a higher plaque burden, but also a higher degree of calcification.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Social and Preventive Medicine

UniBE Contributor:

Schoenenberger, Andreas

ISSN:

0021-9150

Publisher:

Elsevier

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:11

Last Modified:

09 Sep 2017 18:58

Publisher DOI:

10.1016/j.atherosclerosis.2010.06.045

PubMed ID:

20667407

Web of Science ID:

000282678500027

BORIS DOI:

10.7892/boris.2096

URI:

https://boris.unibe.ch/id/eprint/2096 (FactScience: 204280)

Actions (login required)

Edit item Edit item
Provide Feedback