[Inherited alopecia X in Pomeranians]

Mausberg, E M; Drögemüller, Cord; Rüfenacht, S; Welle, Monika Maria; Roosje, Petra; Suter, M; Leeb, Tosso (2007). [Inherited alopecia X in Pomeranians]. DTW. Deutsche tierärztliche Wochenschrift, 114(4), pp. 129-34. Alfeld: Verlag M. & H. Schaper 10.2377/0341-6593-114-129

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Four male Pomeranians that showed alopecia with an age of onset between five months and eight years were investigated.The aim of the investigation was to clarify whether the affected dogs had alopecia X and whether their symptoms might be due to a hereditary defect.The four affected dogs showed hairless patches at the root of the tail, at the back, at the limbs from the thigh to the tarsus and at the abdomen. Within the hairless patches some islets with sparse hair were present. In hairless patches the skin was dark pigmented. Besides the alopecia and hyperpigmentation no other symptoms were found according to anamnestic and clinical examination. History, clinical examinations, laboratory diagnostics, and histopathology of skin biopsies allowed the diagnosis of alopecia X in three affected male dogs.The last one of the affected dogs additionally had slightly reduced thyroid hormone levels. Based on identical symptoms and the close relatedness of all four animals, it was assumed that the fourth affected dog also had alopecia X.The available data possibly indicate a monogenic autosomal dominant inheritance, however a recessive inheritance can not be excluded at this time.

Item Type:

Journal Article (Original Article)

Division/Institute:

05 Veterinary Medicine > Department of Clinical Research and Veterinary Public Health (DCR-VPH) > Institute of Genetics
05 Veterinary Medicine > Department of Clinical Veterinary Medicine (DKV) > DKV - Dermatology
05 Veterinary Medicine > Department of Infectious Diseases and Pathobiology (DIP) > Institute of Animal Pathology

UniBE Contributor:

Mausberg, Eva-Maria; Drögemüller, Cord; Rüfenacht, Silvia; Welle, Monika Maria; Roosje, Petra; Suter, Maja and Leeb, Tosso

Subjects:

500 Science > 590 Animals (Zoology)
600 Technology > 630 Agriculture

ISSN:

0341-6593

Publisher:

Verlag M. & H. Schaper

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:50

Last Modified:

16 Feb 2015 08:04

Publisher DOI:

10.2377/0341-6593-114-129

PubMed ID:

17484499

Web of Science ID:

000246243900002

URI:

https://boris.unibe.ch/id/eprint/21157 (FactScience: 5122)

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