Influence of secondary infection on amputation in chronic critical limb ischemia

Jaccard, Y; Walther, S; Anderson, S; Tauber, M; Kummer, O; Baumgartner, R; Diehm, N; Dörffler-Melly, J; Baumgartner, I (2007). Influence of secondary infection on amputation in chronic critical limb ischemia. European journal of vascular and endovascular surgery EJVES, 33(5), pp. 605-9. London: Elsevier 10.1016/j.ejvs.2006.11.027

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OBJECTIVES: To evaluate the influence of secondary infection on major amputation in chronic critical leg ischemia (CLI). DESIGN: Prospective, controlled observational study. MATERIALS AND METHODS: Sixty-seven patients with CLI and ischemic lesions participated in the study. Presence of infection was defined by clinical, laboratory and radiological criteria. Patients were categorized as having no local infection, soft tissue infection or osteomyelitis treated without antibiotics, amoxicillin/clavulanacid for 1 month or ciprofloxacin and clindamycin for 3 months, respectively. Clinical outcome was assessed at 2, 6 and 12 months. Study endpoints were major amputation and mortality. Analyses were performed using the Kaplan-Meier method. RESULTS: Forty-seven of 67 patients had a local infection. Major amputation was lower in patients with successful revascularization as compared to patients unsuitable for or with failed (without) revascularization (0% vs 26%, p<0.01). In patients with successful revascularization the probability of complete healing was lower with secondary infection (23% vs 71%, p=0.03). In patients without revascularization complete healing was rare (<10%), but secondary infection did not influenced major amputation, mortality or serious adverse events. CONCLUSION: Secondary infection reduces the likelihood of successful healing following revascularisation of CLI.

Item Type:

Journal Article (Original Article)


04 Faculty of Medicine > Department of Radiology, Neuroradiology and Nuclear Medicine (DRNN) > Institute of Diagnostic, Interventional and Paediatric Radiology
04 Faculty of Medicine > Department of Cardiovascular Disorders (DHGE) > Clinic of Angiology

UniBE Contributor:

Anderson, Suzanne E. and Baumgartner, Iris










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Date Deposited:

04 Oct 2013 14:51

Last Modified:

06 Dec 2013 13:44

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URI: (FactScience: 7348)

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