Preclinical testing of strategies for therapeutic targeting of human T-cell trafficking in vivo

Coisne, Caroline; Engelhardt, Britta (2010). Preclinical testing of strategies for therapeutic targeting of human T-cell trafficking in vivo. Methods in molecular biology, 616, pp. 268-281. Totowa, N.J.: Humana Press 10.1007/978-1-60761-461-6_17

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Naive T cells are migratory cells that continuously recirculate between blood and lymphoid tissues. Antigen-specific stimulation of T cells within the lymph nodes reprograms the trafficking properties of T cells by inducing a specific set of adhesion molecules and chemokine receptors on their surface which allow these activated and effector T cells to effectively and specifically home to extralymphoid organs. The observations of organ-specific homing of T cells initiated the development of therapeutic strategies targeting adhesion receptors for organ-specific inhibition of chronic inflammation. As most adhesion receptors have additional immune functions besides mediating leukocyte trafficking, these drugs may have additional immunomodulatory effects. Therapeutic targeting of T-cell trafficking to the central nervous system is the underlying concept of a novel treatment of relapsing remitting multiple sclerosis with the humanized anti-alpha-4-integrin antibody natalizumab. In this chapter, we describe a possible preclinical in vivo approach to directly visualize the therapeutic efficacy of a given drug in inhibiting T-cell homing to a certain organ at the example of the potential of natalizumab to inhibit the trafficking of human T cells to the inflamed central nervous system in an animal model of multiple sclerosis.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > Theodor Kocher Institute

UniBE Contributor:

Coisne, Caroline Marie and Engelhardt, Britta

ISSN:

1064-3745

Publisher:

Humana Press

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:11

Last Modified:

26 Feb 2016 14:43

Publisher DOI:

10.1007/978-1-60761-461-6_17

PubMed ID:

20379881

URI:

https://boris.unibe.ch/id/eprint/2155 (FactScience: 204411)

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