PSGL-1 is dispensible for the development of active experimental autoimmune encephalomyelitis in SJL/J mice

Bill, Ruben; Döring, Axinia; Deutsch, Urban; Engelhardt, Britta (2011). PSGL-1 is dispensible for the development of active experimental autoimmune encephalomyelitis in SJL/J mice. Journal of neuroimmunology, 232(1-2), pp. 207-8. Amsterdam: Elsevier 10.1016/j.jneuroim.2010.10.008

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The adhesion molecule P-selectin glycoprotein ligand (PSGL)-1 has been suggested to be involved in the immunopathogenesis of multiple sclerosis (MS). However, in C57BL/6 mice PSGL-1 was found to be dispensible for the development of MOG(aa35-55)-induced experimental autoimmune encephalomyelitis (EAE), an animal model for MS. To study, if involvement of PSGL-1 to EAE pathogenesis can be observed in another common mouse model, we backcrossed PSGL-1(-/-) mice for at least 12 generations into the SJL/J background and compared PLP(aa139-151) induced EAE in PSGL-1(-/-) SJL/J mice versus wild-type SJL/J mice. Here, we demonstrate that PSGL-1(-/-) SJL/J mice exhibited EAE pathogenesis indistinguishable from wild-type SJL/J mice. Our present study underscores and emphasizes previous observations that PSGL-1 is dispensible for EAE pathogenesis.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > Theodor Kocher Institute

UniBE Contributor:

Deutsch, Urban and Engelhardt, Britta

ISSN:

0165-5728

Publisher:

Elsevier

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:11

Last Modified:

06 Dec 2013 13:22

Publisher DOI:

10.1016/j.jneuroim.2010.10.008

PubMed ID:

21051092

Web of Science ID:

000289493700029

URI:

https://boris.unibe.ch/id/eprint/2156 (FactScience: 204412)

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