Differential expression of the bone and the liver tissue non-specific alkaline phosphatase isoforms in brain tissues

Brun-Heath, Isabelle; Ermonval, Myriam; Chabrol, Elodie; Xiao, Jinsong; Palkovits, Miklós; Lyck, Ruth; Miller, Florence; Couraud, Pierre-Olivier; Mornet, Etienne; Fonta, Caroline (2011). Differential expression of the bone and the liver tissue non-specific alkaline phosphatase isoforms in brain tissues. Cell and tissue research, 343(3), pp. 521-36. Heidelberg: Springer 10.1007/s00441-010-1111-4

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The enzyme tissue non-specific alkaline phosphatase (TNAP) belongs to the ectophosphatase family. It is present in large amounts in bone in which it plays a role in mineralization but little is known about its function in other tissues. Arguments are accumulating for its involvement in the brain, in particular in view of the neurological symptoms accompanying human TNAP deficiencies. We have previously shown, by histochemistry, alkaline phosphatase (AP) activity in monkey brain vessels and parenchyma in which AP exhibits specific patterns. Here, we clearly attribute this activity to TNAP expression rather than to other APs in primates (human and marmoset) and in rodents (rat and mouse). We have not found any brain-specific transcripts but our data demonstrate that neuronal and endothelial cells exclusively express the bone TNAP transcript in all species tested, except in mouse neurons in which liver TNAP transcripts have also been detected. Moreover, we highlight the developmental regulation of TNAP expression; this also acts during neuronal differentiation. Our study should help to characterize the regulation of the expression of this ectophosphatase in various cell types of the central nervous system.

Item Type:

Journal Article (Original Article)


04 Faculty of Medicine > Pre-clinic Human Medicine > Theodor Kocher Institute

UniBE Contributor:

Lyck, Ruth








Factscience Import

Date Deposited:

04 Oct 2013 14:11

Last Modified:

17 Mar 2015 19:13

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Web of Science ID:



https://boris.unibe.ch/id/eprint/2160 (FactScience: 204416)

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