Vashist, Yogesh-K; Tiffon, Celine; Stoupis, Christoforos; Redaelli, Claudio-A (2006). Inhibition of hepatic tumor cell proliferation in vitro and tumor growth in vivo by taltobulin, a synthetic analogue of the tripeptide hemiasterlin. World journal of gastroenterology, 12(42), pp. 6771-6778. Tokyo: WJG Press 10.3748/wjg.v12.i42.6771
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AIM: To investigate the inhibitory effects of taltobulin (HTI-286), a synthetic analogue of natural hemiasterlin derived from marine sponges, on hepatic tumor growth in vitro and in vivo. METHODS: The potential anti-proliferative effects of HTI-286 on different hepatic tumor cell lines in vitro and in vivo were examined. RESULTS: HTI-286 significantly inhibited proliferation of all three hepatic tumor cell lines (mean IC50 = 2 nmol/L +/- 1 nmol/L) in vitro. Interestingly, no decrease in viable primary human hepatocytes (PHH) was detected under HTI-286 exposure. Moreover, intravenous administration of HTI-286 significantly inhibited tumor growth in vivo (rat allograft model). CONCLUSION: HTI-286 might be considered a potent promising drug in treatment of liver malignancies. HTI-286 is currently undergoing clinical evaluation in cancer patients.
Item Type: |
Journal Article (Original Article) |
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Division/Institute: |
04 Faculty of Medicine > Department of Radiology, Neuroradiology and Nuclear Medicine (DRNN) > Institute of Diagnostic, Interventional and Paediatric Radiology |
UniBE Contributor: |
Stoupis, Christoforos |
ISSN: |
1007-9327 |
ISBN: |
17106924 |
Publisher: |
WJG Press |
Language: |
English |
Submitter: |
Factscience Import |
Date Deposited: |
04 Oct 2013 14:51 |
Last Modified: |
05 Dec 2022 14:16 |
Publisher DOI: |
10.3748/wjg.v12.i42.6771 |
PubMed ID: |
17106924 |
Web of Science ID: |
000242105400006 |
BORIS DOI: |
10.48350/21618 |
URI: |
https://boris.unibe.ch/id/eprint/21618 (FactScience: 8900) |