Application of headspace solid phase microextraction to qualitative and quantitative analysis of tobacco additives in cigarettes

Merckel, Careen; Pragst, Fritz; Ratzinger, Astrid; Aebi, Beat; Bernhard, Werner; Sporkert, Frank (2006). Application of headspace solid phase microextraction to qualitative and quantitative analysis of tobacco additives in cigarettes. Journal of chromatography A, 1116(1-2), pp. 10-9. Amsterdam: Elsevier Science 10.1016/j.chroma.2006.03.010

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Cigarettes may contain up to 10% by weight additives which are intended to make them more attractive. A fast and rugged method for a cigarette-screening for additives with medium volatility was developed using automatic headspace solid phase microextraction (HS-SPME) with a 65 microm carbowax-divinylbenzene fiber and gas chromatography-mass spectrometry (GC-MS) with standard electron impact ionisation. In three runs, each cigarette sample was extracted in closed headspace vials using basic, acidic and neutral medium containing 0.5 g NaCl or Na2SO4. Furthermore, the method was optimized for quantitative determination of 17 frequently occurring additives. The practical applicability of the method was demonstrated for cigarettes from 32 brands.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Service Sector > Institute of Legal Medicine > Forensic Chemistry and Toxicology
04 Faculty of Medicine > Service Sector > Institute of Legal Medicine

UniBE Contributor:

Aebi, Beat and Bernhard, Werner

ISSN:

0021-9673

ISBN:

16580003

Publisher:

Elsevier Science

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:51

Last Modified:

10 Jul 2014 15:11

Publisher DOI:

10.1016/j.chroma.2006.03.010

PubMed ID:

16580003

Web of Science ID:

000237680300002

URI:

https://boris.unibe.ch/id/eprint/21622 (FactScience: 8944)

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