Bacterial decontamination of surgical wounds treated with Lavasept

Fabry, Werner; Trampenau, Carola; Bettag, Christian; Handschin, Alexander E; Lettgen, Bernhard; Huber, Franz-Xaver; Hillmeier, Joachim; Kock, Hans-Jürgen (2006). Bacterial decontamination of surgical wounds treated with Lavasept. International journal of hygiene and environmental health, 209(6), pp. 567-73. Amsterdam: Elsevier 10.1016/j.ijheh.2006.03.008

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In a prospective randomized controlled double-blind study in 50 acutely injured patients, bacterially contaminated type 2-4 soft tissue wounds were treated with moist dressings of 0.2% Lavasept (fractionated polyhexamethylenbiguanide and macrogolum 4000) solution (n=28) in comparison with Ringer solution (n=22). Standardized swabs were taken on days 0, 2, 8 and 15 and investigated for microorganisms. For a quantitative evaluation, the number of colony forming units (CFU) was determined by a serial dilution technique. The tissue compatibility and anti-inflammatory effect were rated on a scale of 0 (=bad) to 3 (=very good). The most frequently found microorganism was Staphylococcus aureus, which was isolated from 13 wounds. Use of Lavasept led to a faster and significant reduction in microorganisms on the wound surfaces. The number of CFU per wound remained constant or decreased, in contrast to the wounds treated with Ringer solution. This was true for both Gram-positive and Gram-negative bacteria. There was no evidence of impaired wound healing in either group. The anti-inflammatory effect and the tissue compatibility of Lavasept were rated significantly better than that of Ringer solution. It is concluded that Lavasept combines antiseptic action with good tissue compatibility.

Item Type:

Journal Article (Original Article)


04 Faculty of Medicine > Department of Orthopaedic, Plastic and Hand Surgery (DOPH) > Clinic of Plastic and Hand Surgery > Plastic, Reconstructive and Aesthetic Surgery

UniBE Contributor:

Handschin, Alexander










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Date Deposited:

04 Oct 2013 14:51

Last Modified:

17 Mar 2015 21:55

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URI: (FactScience: 13455)

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