How does spatial extent of fMRI datasets affect independent component analysis decomposition?

Aragri, Adriana; Scarabino, Tommaso; Seifritz, Erich; Comani, Silvia; Cirillo, Sossio; Tedeschi, Gioacchino; Esposito, Fabrizio; Di Salle, Francesco (2006). How does spatial extent of fMRI datasets affect independent component analysis decomposition? Human brain mapping, 27(9), pp. 736-46. Hoboken, N.J.: Wiley-Blackwell 10.1002/hbm.20215

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Spatial independent component analysis (sICA) of functional magnetic resonance imaging (fMRI) time series can generate meaningful activation maps and associated descriptive signals, which are useful to evaluate datasets of the entire brain or selected portions of it. Besides computational implications, variations in the input dataset combined with the multivariate nature of ICA may lead to different spatial or temporal readouts of brain activation phenomena. By reducing and increasing a volume of interest (VOI), we applied sICA to different datasets from real activation experiments with multislice acquisition and single or multiple sensory-motor task-induced blood oxygenation level-dependent (BOLD) signal sources with different spatial and temporal structure. Using receiver operating characteristics (ROC) methodology for accuracy evaluation and multiple regression analysis as benchmark, we compared sICA decompositions of reduced and increased VOI fMRI time-series containing auditory, motor and hemifield visual activation occurring separately or simultaneously in time. Both approaches yielded valid results; however, the results of the increased VOI approach were spatially more accurate compared to the results of the decreased VOI approach. This is consistent with the capability of sICA to take advantage of extended samples of statistical observations and suggests that sICA is more powerful with extended rather than reduced VOI datasets to delineate brain activity.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > University Psychiatric Services > University Hospital of Psychiatry and Psychotherapy > Management

UniBE Contributor:

Seifritz, Erich

ISSN:

1065-9471

ISBN:

16447211

Publisher:

Wiley-Blackwell

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:51

Last Modified:

17 Mar 2015 21:55

Publisher DOI:

10.1002/hbm.20215

PubMed ID:

16447211

Web of Science ID:

000239849900004

URI:

https://boris.unibe.ch/id/eprint/21766 (FactScience: 13619)

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