Bacterial profile and burden of periodontal infection in subjects with a diagnosis of acute coronary syndrome

Renvert, Stefan; Pettersson, Thomas; Ohlsson, Ola; Persson, Gösta Rutger (2006). Bacterial profile and burden of periodontal infection in subjects with a diagnosis of acute coronary syndrome. Journal of periodontology, 77(7), pp. 1110-9. Chicago, Ill.: American Academy of Periodontology 10.1902/jop.2006.050336

Full text not available from this repository.

BACKGROUND: Periodontitis has been identified as a potential risk factor in cardiovascular diseases. It is possible that the stimulation of host responses to oral infections may result in vascular damage and the inducement of blood clotting. The aim of this study was to assess the role of periodontal infection and bacterial burden as an explanatory variable to the activation of the inflammatory process leading to acute coronary syndrome (ACS). METHODS: A total of 161 consecutive surviving cases admitted with a diagnosis of ACS and 161 control subjects, matched with cases according to their gender, socioeconomic level, and smoking status, were studied. Serum white blood cell (WBC) counts, high- and low-density lipoprotein (HDL/LDL) levels, high-sensitivity C-reactive protein (hsC-rp) levels, and clinical periodontal routine parameters were studied. The subgingival pathogens were assayed by the checkerboard DNA-DNA hybridization method. RESULTS: Total oral bacterial load was higher in the subjects with ACS (mean difference: 17.4x10(5); SD: 10.8; 95% confidence interval [CI]: 4.2 to 17.4; P<0.001), and significant for 26 of 40 species including Porphyromonas gingivalis, Tannerella forsythensis, and Treponema denticola. Serum WBC counts, hsC-rp levels, Streptococcus intermedius, and Streptococcus sanguis, were explanatory factors to acute coronary syndrome status (Nagelkerke r2=0.49). CONCLUSION: The oral bacterial load of S. intermedius, S. sanguis, Streptococcus anginosus, T. forsythensis, T. denticola, and P. gingivalis may be concomitant risk factors in the development of ACS.

Item Type:	Journal Article (Original Article)
Division/Institute:	04 Faculty of Medicine > School of Dental Medicine > Department of Periodontology
UniBE Contributor:	Renvert, Stefan, Persson, Gösta Rutger
Subjects:	600 Technology > 610 Medicine & health
ISSN:	0022-3492
Publisher:	American Academy of Periodontology
Submitter:	Eveline Carmen Schuler
Date Deposited:	04 Oct 2013 14:52
Last Modified:	05 Dec 2022 14:16
Publisher DOI:	10.1902/jop.2006.050336
PubMed ID:	16805672
Web of Science ID:	000241879200003
URI:	https://boris.unibe.ch/id/eprint/21813 (FactScience: 15135)