Bacterial profile and burden of periodontal infection in subjects with a diagnosis of acute coronary syndrome

Renvert, Stefan; Pettersson, Thomas; Ohlsson, Ola; Persson, Gösta Rutger (2006). Bacterial profile and burden of periodontal infection in subjects with a diagnosis of acute coronary syndrome. Journal of periodontology, 77(7), pp. 1110-9. Chicago, Ill.: American Academy of Periodontology 10.1902/jop.2006.050336

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BACKGROUND: Periodontitis has been identified as a potential risk factor in cardiovascular diseases. It is possible that the stimulation of host responses to oral infections may result in vascular damage and the inducement of blood clotting. The aim of this study was to assess the role of periodontal infection and bacterial burden as an explanatory variable to the activation of the inflammatory process leading to acute coronary syndrome (ACS). METHODS: A total of 161 consecutive surviving cases admitted with a diagnosis of ACS and 161 control subjects, matched with cases according to their gender, socioeconomic level, and smoking status, were studied. Serum white blood cell (WBC) counts, high- and low-density lipoprotein (HDL/LDL) levels, high-sensitivity C-reactive protein (hsC-rp) levels, and clinical periodontal routine parameters were studied. The subgingival pathogens were assayed by the checkerboard DNA-DNA hybridization method. RESULTS: Total oral bacterial load was higher in the subjects with ACS (mean difference: 17.4x10(5); SD: 10.8; 95% confidence interval [CI]: 4.2 to 17.4; P<0.001), and significant for 26 of 40 species including Porphyromonas gingivalis, Tannerella forsythensis, and Treponema denticola. Serum WBC counts, hsC-rp levels, Streptococcus intermedius, and Streptococcus sanguis, were explanatory factors to acute coronary syndrome status (Nagelkerke r2=0.49). CONCLUSION: The oral bacterial load of S. intermedius, S. sanguis, Streptococcus anginosus, T. forsythensis, T. denticola, and P. gingivalis may be concomitant risk factors in the development of ACS.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > School of Dental Medicine > Department of Periodontology

UniBE Contributor:

Renvert, Stefan and Persson, Gösta Rutger

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0022-3492

Publisher:

American Academy of Periodontology

Submitter:

Eveline Carmen Schuler

Date Deposited:

04 Oct 2013 14:52

Last Modified:

25 Jan 2017 12:17

Publisher DOI:

10.1902/jop.2006.050336

PubMed ID:

16805672

Web of Science ID:

000241879200003

URI:

https://boris.unibe.ch/id/eprint/21813 (FactScience: 15135)

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