Adjunctive local antibiotic therapy in the treatment of peri-implantitis II: clinical and radiographic outcomes

Salvi, Giovanni E; Persson, Gösta Rutger; Heitz-Mayfield, Lisa; Frei, Marc; Lang, Niklaus Peter (2007). Adjunctive local antibiotic therapy in the treatment of peri-implantitis II: clinical and radiographic outcomes. Clinical oral implants research, 18(3), pp. 281-285. Oxford: Wiley-Blackwell 10.1111/j.1600-0501.2007.01377.x

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AIM: To monitor over 12 months clinical and radiographic changes occurring after adjunctive local delivery of minocycline microspheres for the treatment of peri-implantitis. MATERIAL AND METHODS: In 25 partially edentulous subjects, 31 implants diagnosed with peri-implantitis were treated. Three weeks after oral hygiene instruction, mechanical debridement and local antiseptic cleansing using 0.2% chlorhexidine gel, baseline (Day 0) parameters were recorded. Minocycline microspheres (Arestin) were locally delivered to each implant site with bone loss and a probing pocket depth (PPD) >or=5 mm. Rescue therapy with Arestin was allowed at Days 180 and 270 at any site exhibiting an increase in PPD>or=2 mm from the previous visit. The following clinical parameters were recorded at four sites/implant at Day 0, 10, 30, 60, 90, 180, 270 and 360: PPD, clinical attachment level (CAL), bleeding on probing (BOP) and plaque index (PlI). RESULTS: Six implants in six subjects were either rescued or exited because of persisting active peri-implantitis. Successful implants showed a statistically significant reduction in both PPD and percentage of sites with BOP between baseline and Day 360 (P<0.05). At mesial implant sites, the mean PPD reduction amounted to 1.6 mm (95% CI: 0.9-2.2 mm, P<0.001) and was accompanied by a statistically significant reduction of the BOP value (P<0.001). Binary regression analysis showed that the clinical parameters and smoking history could not discriminate between successfully treated and rescued or exited implants at any observation time point. CONCLUSION: Non-surgical mechanical treatment of peri-implantitis lesions with adjunctive local delivery of microencapsulated minocycline led to positive effects on clinical parameters up to 12 months.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > School of Dental Medicine > Department of Periodontology
04 Faculty of Medicine > School of Dental Medicine > Department of Oral Surgery and Stomatology

UniBE Contributor:

Salvi, Giovanni; Persson, Gösta Rutger; Heitz-Mayfield, Lisa; Frei, Marc and Lang, Niklaus Peter

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0905-7161

Publisher:

Wiley-Blackwell

Submitter:

Eveline Carmen Schuler

Date Deposited:

04 Oct 2013 14:52

Last Modified:

25 Jan 2017 12:17

Publisher DOI:

10.1111/j.1600-0501.2007.01377.x

PubMed ID:

17355354

Web of Science ID:

000247240800003

BORIS DOI:

10.7892/boris.21841

URI:

https://boris.unibe.ch/id/eprint/21841 (FactScience: 15282)

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