Serum markers for predicting pre-eclampsia

Baumann, Marc U; Bersinger, Nick A; Surbek, Daniel V (2007). Serum markers for predicting pre-eclampsia. Molecular aspects of medicine, 28(2), pp. 227-44. Amsterdam: Elsevier 10.1016/j.mam.2007.04.002

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Pre-eclampsia, a pregnancy-specific disorder, contributes substantially to perinatal morbidity and mortality of both, mother and newborn. An increasing number of biochemical agents were evaluated as markers for predicting pre-eclampsia. None of them has been proved to be of clinical value yet. Much effort has been put into assessing novel potential markers and their combination with other screening methods such as Doppler sonography. The purpose of this review is to reflect the current knowledge of serum markers for predicting pre-eclampsia. So far, the most promising serum markers are placental protein 13 (PP-13), as well as soluble fms-like tyrosine kinase-1 (sFlt-1), placental growth factor (PIGF) and soluble endoglin (sEng). These markers allow screening at a relatively early stage and, most importantly, show relatively high predictive values and improved diagnostic performance if combined with first trimester Doppler sonography. Large-scale prospective studies, assessing these markers, are important to justify their clinical use in view of early intervention to prevent pre-eclampsia in the future.

Item Type:

Journal Article (Further Contribution)

Division/Institute:

04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Gynaecology

UniBE Contributor:

Baumann, Marc; Bersinger, Nick A. and Surbek, Daniel

ISSN:

0098-2997

ISBN:

17532461

Publisher:

Elsevier

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:52

Last Modified:

06 Dec 2013 13:44

Publisher DOI:

10.1016/j.mam.2007.04.002

PubMed ID:

17532461

Web of Science ID:

000247975400005

URI:

https://boris.unibe.ch/id/eprint/21846 (FactScience: 16077)

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