The Young's modulus of fetal preterm and term amniotic membranes

Benson-Martin, Janine; Zammaretti, Prisca; Bilic, Grozdana; Schweizer, Thomas; Portmann-Lanz, Bettina; Burkhardt, Tilo; Zimmermann, Roland; Ochsenbein-Kölble, Nicole (2006). The Young's modulus of fetal preterm and term amniotic membranes. European journal of obstetrics & gynecology and reproductive biology, 128(1-2), pp. 103-7. Shannon: Elsevier 10.1016/j.ejogrb.2005.12.011

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OBJECTIVE: To examine the Young's modulus of the human amniotic membranes, as well as its relationship to gestational age. To determine whether cellular and material-related parameters affect this modulus. STUDY DESIGN: In a prospective study at the Obstetric outpatient clinic of the University Hospital Zurich Young's modulus, thickness and mesenchymal:epithelial cell ratio of amniotic membranes of preterm (N=23) and term (N=40) placentae were examined. Significance (P<0.05) was calculated with the Mann-Whitney two-sample rank sum test and Wilcoxon signed rank test, while correlations were made using the Spearman's correlation. RESULTS: The Young's modulus of preterm amniotic membranes was significantly higher than that of term membranes. It varied within the same amniotic membrane. The thickness of the amnion in both preterm and term membranes did not differ significantly. The thinner the preterm and term amniotic membranes, the higher the Young's modulus was. There was no relation to the mesenchymal:epithelial cell ratio in the amnion. CONCLUSIONS: Preterm amniotic membranes are stiffer than term amniotic membranes. Tentatively, we hypothesise that there may be a correlation between the extracellular matrix components and the elastic properties of the membrane.

Item Type:	Journal Article (Original Article)
Division/Institute:	04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Gynaecology
UniBE Contributor:	Portmann-Lanz, Bettina
ISSN:	0301-2115
ISBN:	16442204
Publisher:	Elsevier
Language:	English
Submitter:	Factscience Import
Date Deposited:	04 Oct 2013 14:52
Last Modified:	05 Dec 2022 14:16
Publisher DOI:	10.1016/j.ejogrb.2005.12.011
PubMed ID:	16442204
Web of Science ID:	000240909100019
URI:	https://boris.unibe.ch/id/eprint/21950 (FactScience: 20036)