Atrial septal defect closure in a patient with "irreversible" pulmonary hypertensive arteriopathy

Schwerzmann, Markus; Zafar, Moiz; McLaughlin, Peter R; Chamberlain, Dean W; Webb, Gary; Granton, John (2006). Atrial septal defect closure in a patient with "irreversible" pulmonary hypertensive arteriopathy. International journal of cardiology, 110(1), pp. 104-7. Amsterdam: Elsevier 10.1016/j.ijcard.2005.05.062

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The presence of irreversible pulmonary hypertension in patients with atrial septal defect (ASD) is thought to preclude shunt closure. We report the case of a woman with plexiform pulmonary arteriopathy secondary to an ostium secundum ASD who was able to successfully undergo percutaneous shunt closure following therapy with chronic intravenous prostacyclin (Flolan). One year after closure, the patient was weaned off Flolan over a period of 7 months following the institution of oral Bosentan therapy. Our case illustrates how aggressive vasodilator therapy with prostaglandins may be capable of reducing pulmonary artery pressure and permitting shunt closure in a patient once considered to have "inoperable" pulmonary arteriopathy.

Item Type:	Journal Article (Original Article)
Division/Institute:	04 Faculty of Medicine > Department of Cardiovascular Disorders (DHGE) > Clinic of Cardiology
UniBE Contributor:	Schwerzmann, Markus
ISSN:	0167-5273
ISBN:	15992947
Publisher:	Elsevier
Language:	English
Submitter:	Factscience Import
Date Deposited:	04 Oct 2013 14:52
Last Modified:	05 Dec 2022 14:16
Publisher DOI:	10.1016/j.ijcard.2005.05.062
PubMed ID:	15992947
Web of Science ID:	000238298400021
URI:	https://boris.unibe.ch/id/eprint/21961 (FactScience: 20558)