Atrial septal defect closure in a patient with "irreversible" pulmonary hypertensive arteriopathy

Schwerzmann, Markus; Zafar, Moiz; McLaughlin, Peter R; Chamberlain, Dean W; Webb, Gary; Granton, John (2006). Atrial septal defect closure in a patient with "irreversible" pulmonary hypertensive arteriopathy. International journal of cardiology, 110(1), pp. 104-7. Amsterdam: Elsevier 10.1016/j.ijcard.2005.05.062

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The presence of irreversible pulmonary hypertension in patients with atrial septal defect (ASD) is thought to preclude shunt closure. We report the case of a woman with plexiform pulmonary arteriopathy secondary to an ostium secundum ASD who was able to successfully undergo percutaneous shunt closure following therapy with chronic intravenous prostacyclin (Flolan). One year after closure, the patient was weaned off Flolan over a period of 7 months following the institution of oral Bosentan therapy. Our case illustrates how aggressive vasodilator therapy with prostaglandins may be capable of reducing pulmonary artery pressure and permitting shunt closure in a patient once considered to have "inoperable" pulmonary arteriopathy.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Cardiovascular Disorders (DHGE) > Clinic of Cardiology

UniBE Contributor:

Schwerzmann, Markus

ISSN:

0167-5273

ISBN:

15992947

Publisher:

Elsevier

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:52

Last Modified:

17 Mar 2015 21:55

Publisher DOI:

10.1016/j.ijcard.2005.05.062

PubMed ID:

15992947

Web of Science ID:

000238298400021

URI:

https://boris.unibe.ch/id/eprint/21961 (FactScience: 20558)

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