Surmely, Jean-François; Nasu, Kenya; Fujita, Hiroshi; Terashima, Mitsuyasu; Matsubara, Tetsuo; Tsuchikane, Etsuo; Ehara, Mariko; Kinoshita, Yoshihisa; Zheng, Quan Xiu; Tanaka, Nobuyoshi; Katoh, Osamu; Suzuki, Takahiko (2006). Coronary plaque composition of culprit/target lesions according to the clinical presentation: a virtual histology intravascular ultrasound analysis. European Heart Journal, 27(24), pp. 2939-44. Oxford: Oxford University Press 10.1093/eurheartj/ehl285
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AIMS: To evaluate the plaque composition obtained by virtual histology (VH) IVUS according to the clinical presentation and to compare those data to previously published histopathology data. METHODS AND RESULTS: VH was performed on 95 de novo significant lesions (>75% stenosis) in 85 patients [28 acute coronary syndrome (ACS) patients, 30 lesions; 57 stable angina pectoris (SAP) patients, 65 lesions]. There were a higher prevalence of positive remodelling (47 vs. 22%, P=0.013), thrombus (20 vs. 1.5%, P=0.0037), and echo-lucent area (23.3 vs. 7.7%, P=0.047) in ACS patients. At the minimal lumen site, fibrous plaque area was significantly larger in ACS lesions than in SAP lesions (66.0+/-10.7 vs. 61.4+/-8.9%, P=0.034), whereas necrotic core and dense calcium plaque area were smaller in ACS lesions (Necrotic core: 6.8+/-6.0 vs. 11.0+/-8.3%, P=0.02; Dense calcium: 2.6+/-3.0 vs. 4.9+/-5.8%, P=0.03). No differences in rate of thin cap fibroatheroma, thick fibrotheroma, or for the presence of multiple necrotic core layers were observed between both groups. CONCLUSION: Plaque composition obtained by VH-IVUS shows less necrotic core and more fibrous tissue in ACS compared to SAP lesions, which is in contradiction with previously published histopathologic data.
Item Type: |
Journal Article (Original Article) |
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Division/Institute: |
04 Faculty of Medicine > Department of Cardiovascular Disorders (DHGE) > Clinic of Cardiology |
UniBE Contributor: |
Surmely, Jean-Francois |
ISSN: |
0195-668X |
ISBN: |
17040929 |
Publisher: |
Oxford University Press |
Language: |
English |
Submitter: |
Factscience Import |
Date Deposited: |
04 Oct 2013 14:52 |
Last Modified: |
05 Dec 2022 14:16 |
Publisher DOI: |
10.1093/eurheartj/ehl285 |
PubMed ID: |
17040929 |
Web of Science ID: |
000242715900013 |
BORIS DOI: |
10.48350/21962 |
URI: |
https://boris.unibe.ch/id/eprint/21962 (FactScience: 20560) |
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