Coronary plaque composition of culprit/target lesions according to the clinical presentation: a virtual histology intravascular ultrasound analysis

Surmely, Jean-François; Nasu, Kenya; Fujita, Hiroshi; Terashima, Mitsuyasu; Matsubara, Tetsuo; Tsuchikane, Etsuo; Ehara, Mariko; Kinoshita, Yoshihisa; Zheng, Quan Xiu; Tanaka, Nobuyoshi; Katoh, Osamu; Suzuki, Takahiko (2006). Coronary plaque composition of culprit/target lesions according to the clinical presentation: a virtual histology intravascular ultrasound analysis. European Heart Journal, 27(24), pp. 2939-44. Oxford: Oxford University Press 10.1093/eurheartj/ehl373

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AIMS: To evaluate the plaque composition obtained by virtual histology (VH) IVUS according to the clinical presentation and to compare those data to previously published histopathology data. METHODS AND RESULTS: VH was performed on 95 de novo significant lesions (>75% stenosis) in 85 patients [28 acute coronary syndrome (ACS) patients, 30 lesions; 57 stable angina pectoris (SAP) patients, 65 lesions]. There were a higher prevalence of positive remodelling (47 vs. 22%, P=0.013), thrombus (20 vs. 1.5%, P=0.0037), and echo-lucent area (23.3 vs. 7.7%, P=0.047) in ACS patients. At the minimal lumen site, fibrous plaque area was significantly larger in ACS lesions than in SAP lesions (66.0+/-10.7 vs. 61.4+/-8.9%, P=0.034), whereas necrotic core and dense calcium plaque area were smaller in ACS lesions (Necrotic core: 6.8+/-6.0 vs. 11.0+/-8.3%, P=0.02; Dense calcium: 2.6+/-3.0 vs. 4.9+/-5.8%, P=0.03). No differences in rate of thin cap fibroatheroma, thick fibrotheroma, or for the presence of multiple necrotic core layers were observed between both groups. CONCLUSION: Plaque composition obtained by VH-IVUS shows less necrotic core and more fibrous tissue in ACS compared to SAP lesions, which is in contradiction with previously published histopathologic data.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Cardiovascular Disorders (DHGE) > Clinic of Cardiology

UniBE Contributor:

Surmely, Jean-Francois

ISSN:

0195-668X

ISBN:

17040929

Publisher:

Oxford University Press

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:52

Last Modified:

06 Mar 2014 22:32

Publisher DOI:

10.1093/eurheartj/ehl373

PubMed ID:

17040929

Web of Science ID:

000242715900013

URI:

https://boris.unibe.ch/id/eprint/21962 (FactScience: 20560)

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