Genome-wide search for markers associated with osteochondrosis in Hanoverian warmblood horses

Dierks, Claudia; Löhring, Kathrin; Lampe, Virginie; Wittwer, Catherine; Drögemüller, Cord; Distl, Ottmar (2007). Genome-wide search for markers associated with osteochondrosis in Hanoverian warmblood horses. Mammalian genome, 18(10), pp. 739-47. New York, N.Y.: Springer 10.1007/s00335-007-9058-9

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A genome-wide scan was performed to detect quantitative trait loci (QTLs) for osteochondrosis (OC) and osteochondrosis dissecans (OCD) in horses. The marker set comprised 260 microsatellites. We collected data from 211 Hanoverian warmblood horses consisting of 14 paternal half-sib families. Traits used were OC (fetlock and/or hock joints affected), OCD (fetlock and/or hock joints affected), fetlock OC, fetlock OCD, hock OC, and hock OCD. The first genome scan included 172 microsatellite markers. In a second step 88 additional markers were chosen to refine putative QTLs found in the first scan. Genome-wide significant QTLs were located on equine chromosomes 2, 4, 5, and 16. QTLs for fetlock OC and hock OC partly overlapped on the same chromosomes, indicating that these traits may be genetically related. QTLs reached the chromosome-wide significance level on eight different equine chromosomes: 2, 3, 4, 5, 15, 16, 19, and 21. This whole-genome scan was a first step toward the identification of candidate genome regions harboring genes responsible for equine OC. Further investigations are necessary to refine the map positions of the QTLs already identified for OC.

Item Type:

Journal Article (Original Article)

Division/Institute:

05 Veterinary Medicine > Department of Clinical Research and Veterinary Public Health (DCR-VPH) > Institute of Genetics

UniBE Contributor:

Drögemüller, Cord

ISSN:

0938-8990

Publisher:

Springer

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:52

Last Modified:

21 Jan 2014 15:05

Publisher DOI:

10.1007/s00335-007-9058-9

PubMed ID:

17906894

Web of Science ID:

000250442900006

URI:

https://boris.unibe.ch/id/eprint/22133 (FactScience: 32010)

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