Platelet receptors and their role in diseases

Clemetson, KJ (2003). Platelet receptors and their role in diseases. Clinical chemistry and laboratory medicine, 3(41), pp. 253-60. Berlin: De Gruyter 10.1515/CCLM.2003.039

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The absence or deficiency of specific platelet glycoprotein receptors has a well-defined role in causing several rare bleeding disorders such as Bernard-Soulier syndrome or Glanzmann's thrombasthenia. Several new rare disorders caused by defects in other receptors or their signalling pathways have recently been described. Platelet receptors are also often targets for antibodies in pathological conditions. The roles of platelet receptors or their polymorphism variants in diseases such as cardiovascular disorders have started to be intensively investigated over the last 5 years. Many of these findings still remain controversial. Recent evidence points to a fundamental role for platelets and their receptors in the origins of atherosclerosis. Studies on the role of platelet receptors in diseases such as asthma, diabetes and HIV are still at an early stage.

Item Type:

Journal Article (Further Contribution)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > Theodor Kocher Institute

UniBE Contributor:

Clemetson, Kenneth John

ISSN:

1434-6621

ISBN:

12705329

Publisher:

De Gruyter

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:52

Last Modified:

07 Nov 2014 08:03

Publisher DOI:

10.1515/CCLM.2003.039

PubMed ID:

12705329

Web of Science ID:

000182153900001

URI:

https://boris.unibe.ch/id/eprint/22163 (FactScience: 32164)

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