Snake venom L-amino acid oxidases

Du, XY; Clemetson, KJ (2002). Snake venom L-amino acid oxidases. Toxicon, 40(6), pp. 659-65. Oxford: Elsevier 10.1016/S0041-0101(02)00102-2

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L-amino acid oxidases are widely found in snake venoms and are thought to contribute to the toxicity upon envenomation. The mechanism of these toxic effects and whether they result from the enzymatic activity are still uncertain although many papers describing the biological and pharmacological effects of L-amino acid oxidases have appeared recently, which provide more information about their action on platelets, induction of apoptosis, haemorrhagic effects, and cytotoxicity. This review summarizes the physiochemical properties, structural characteristics and various biological functions of snake venom L-amino acid oxidases (SV-LAAOs). In addition, the putative mechanisms of SV-LAAO-induced platelet aggregation and apoptosis of cells are discussed in more detail.

Item Type:

Journal Article (Further Contribution)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > Theodor Kocher Institute

UniBE Contributor:

Clemetson, Kenneth John

ISSN:

0041-0101

ISBN:

12175601

Publisher:

Elsevier

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:52

Last Modified:

04 May 2014 23:15

Publisher DOI:

10.1016/S0041-0101(02)00102-2

PubMed ID:

12175601

Web of Science ID:

000175810700001

URI:

https://boris.unibe.ch/id/eprint/22166 (FactScience: 32170)

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