Collagen receptors as potential targets for novel anti-platelet agents

Clemetson, Kenneth J; Clemetson, Jeannine M (2007). Collagen receptors as potential targets for novel anti-platelet agents. Current pharmaceutical design, 13(26), pp. 2673-83. Hilversum: Bentham Science Publishers 10.2174/138161207781662894

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Platelets have important roles in atherosclerosis and thrombosis and their inhibition reduces the risk of these disorders. There is still a need for platelet inhibitors affecting pathways that reduce thrombosis and atherosclerosis while leaving normal hemostasis relatively unaffected, thus reducing possible bleeding complications. Although combinations show progress in achieving these goals none of the present inhibitors completely fulfill these requirements. Collagen receptors offer attractive possibilities as alternative targets at early stages in platelet activation. Three major collagen receptors are assessed in this review; the alpha2beta1 integrin, responsible primarily for platelet adhesion to collagen; GPVI, the major signaling receptor for collagen; and GPIb-V-IX, which is indirectly a collagen receptor via von Willebrand factor. Several thrombosis models and experimental approaches suggest that all three are interesting targets and merit further investigation.

Item Type:

Journal Article (Further Contribution)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > Theodor Kocher Institute

UniBE Contributor:

Clemetson, Kenneth John

ISSN:

1381-6128

ISBN:

17897011

Publisher:

Bentham Science Publishers

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:52

Last Modified:

04 May 2014 23:15

Publisher DOI:

10.2174/138161207781662894

PubMed ID:

17897011

Web of Science ID:

000249341300007

URI:

https://boris.unibe.ch/id/eprint/22185 (FactScience: 32222)

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