Connexin genes in the mouse and human genome

Eiberger, J; Degen, J; Romualdi, A; Deutsch, U; Willecke, K; Söhl, G (2001). Connexin genes in the mouse and human genome. Cell communication & adhesion, 8(4-6), pp. 163-5. Basingstoke, UK: Taylor & Francis 10.3109/15419060109080717

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Gap junctions serve for direct intercellular communication by docking of two hemichannels in adjacent cells thereby forming conduits between the cytoplasmic compartments of adjacent cells. Connexin genes code for subunit proteins of gap junction channels and are members of large gene families in mammals. So far, 17 connexin (Cx) genes have been described and characterized in the murine genome. For most of them, orthologues in the human genome have been found (see White and Paul 1999; Manthey et al. 1999; Teubner et al. 2001; Söhl et al. 2001). We have recently performed searches for connexin genes in murine and human gene libraries available at EMBL/Heidelberg, NCBI and the Celera company that have increased the number of identified connexins to 19 in mouse and 20 in humans. For one mouse connexin gene and two human connexin genes we did not find orthologues in the other genome. Here we present a short overview on distinct connexin genes which we found in the mouse and human genome and which may include all members of this gene family, if no further connexin gene will be discovered in the remaining non-sequenced parts (about 1-5%) of the genomes.

Item Type:	Journal Article (Original Article)
Division/Institute:	04 Faculty of Medicine > Pre-clinic Human Medicine > Theodor Kocher Institute
UniBE Contributor:	Deutsch, Urban
ISSN:	1541-9061
ISBN:	12064582
Publisher:	Taylor & Francis
Language:	English
Submitter:	Factscience Import
Date Deposited:	04 Oct 2013 14:52
Last Modified:	05 Dec 2022 14:16
Publisher DOI:	10.3109/15419060109080717
PubMed ID:	12064582
Web of Science ID:	000175984300005
URI:	https://boris.unibe.ch/id/eprint/22221 (FactScience: 32296)