Braunschweig, M. H. (2007). Short communication: duplication in the 5'-flanking region of the beta-lactoglobulin gene is linked to the BLG A allele. Journal of dairy science, 90(12), pp. 5780-3. Savoy, Ill.: American Dairy Science Association 10.3168/jds.2007-0491
Full text not available from this repository.beta-Lactoglobulin (beta-LG) is the major whey protein in the milk of cows and other ruminants. It is well established that the predominant genetic variants beta-LG A and B are differentially expressed. Extensive investigation of the genetic variation in the promoter region of the BLG gene revealed the existence of specific haplotypes associated with the A and B variants. However, the genetic basis for the differentially expressed BLG A and B alleles is still elusive. In this study additional genetic variation further upstream in the 5'-flanking region of the BLG gene was identified, including 6 single nucleotide substitutions, a single nucleotide deletion, and a 7-bp duplication. Comparison of DNA sequences showed that the investigated 5'-flanking region is highly conserved between ruminants, and the duplication g.-1885_-1879dupCTCTCGC and the substitution g.-1888A>G are only found in the BLG A and D alleles in cattle. The cytosine at position g.-1957 and the thymines at positions g.-2008 and g.-2049 are only found in BLG B alleles of cattle. It is suggested that the described genetic variability contributes to the differential allelic expression of the BLG gene.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
05 Veterinary Medicine > Department of Clinical Research and Veterinary Public Health (DCR-VPH) > Institute of Genetics |
UniBE Contributor: |
Braunschweig, Martin |
ISSN: |
0022-0302 |
Publisher: |
American Dairy Science Association |
Language: |
English |
Submitter: |
Factscience Import |
Date Deposited: |
04 Oct 2013 14:52 |
Last Modified: |
05 Dec 2022 14:16 |
Publisher DOI: |
10.3168/jds.2007-0491 |
PubMed ID: |
18024772 |
Web of Science ID: |
000251040300049 |
URI: |
https://boris.unibe.ch/id/eprint/22235 (FactScience: 32960) |
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