Vaccination with a T-cell-priming Gag peptide of caprine arthritis encephalitis virus enhances virus replication transiently in vivo

Nenci, Chiara; Zahno, Marie-Luise; Vogt, Hans-Rudolf; Obexer-Ruff, Gaby; Doherr, Marcus G; Zanoni, Reto; Peterhans, Ernst; Bertoni, Giuseppe (2007). Vaccination with a T-cell-priming Gag peptide of caprine arthritis encephalitis virus enhances virus replication transiently in vivo. Journal of general virology, 88(Pt 5), pp. 1589-93. Reading: Society for General Microbiology 10.1099/vir.0.82800-0

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CD4+ T cells are involved in several immune response pathways used to control viral infections. In this study, a group of genetically defined goats was immunized with a synthetic peptide known to encompass an immunodominant helper T-cell epitope of caprine arthritis encephalitis virus (CAEV). Fifty-five days after challenge with the molecularly cloned CAEV strain CO, the vaccinated animals had a higher proviral load than the controls. The measurement of gamma interferon and interleukin-4 gene expression showed that these cytokines were reliable markers of an ongoing immune response but their balance did not account for more or less efficient control of CAEV replication. In contrast, granulocyte-macrophage colony-stimulating factor appeared to be a key cytokine that might support virus replication in the early phase of infection. The observation of a potential T-cell-mediated enhancement of virus replication supports other recent findings showing that lentivirus-specific T cells can be detrimental to the host, suggesting caution in designing vaccine candidates.

Item Type:

Journal Article (Original Article)

Division/Institute:

05 Veterinary Medicine > Department of Clinical Veterinary Medicine (DKV) > DVK - Clinical Research (discontinued)
05 Veterinary Medicine > Department of Clinical Research and Veterinary Public Health (DCR-VPH) > Experimental Clinical Research
05 Veterinary Medicine > Department of Infectious Diseases and Pathobiology (DIP) > Institute of Virology and Immunology
05 Veterinary Medicine > Department of Clinical Research and Veterinary Public Health (DCR-VPH) > Institute of Genetics

UniBE Contributor:

Nenci, Chiara; Zahno, Marie-Luise; Vogt, Hans-Rudolf; Obexer, Gaby; Doherr, Marcus; Zanoni, Reto Giacomo; Peterhans, Ernst and Bertoni, Giuseppe

ISSN:

0022-1317

Publisher:

Society for General Microbiology

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:52

Last Modified:

03 Feb 2015 10:43

Publisher DOI:

10.1099/vir.0.82800-0

PubMed ID:

17412991

Web of Science ID:

000246532300026

URI:

https://boris.unibe.ch/id/eprint/22249 (FactScience: 33593)

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