Neuropathological and molecular comparison between clinical and asymptomatic bovine spongiform encephalopathy cases

Sisó, Silvia; Doherr, Marcus G; Botteron, Catherine; Fatzer, Rosemarie; Zurbriggen, Andreas; Vandevelde, Marc; Seuberlich, Torsten (2007). Neuropathological and molecular comparison between clinical and asymptomatic bovine spongiform encephalopathy cases. Acta neuropathologica, 114(5), pp. 501-8. Berlin: Springer-Verlag 10.1007/s00401-007-0283-9

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Interest in the proper neuropathological and molecular characterization of bovine spongiform encephalopathy (BSE) has increased since asymptomatic and atypical cases were detected in the cattle population by active disease surveillance. In this respect we investigated a total of 95 confirmed BSE cases originating from different active and passive surveillance categories (clinical suspects, emergency-slaughter, fallen stock and routinely slaughter) in Switzerland for their neuropathological and molecular phenotype. We looked for measurable differences between these categories in lesion profile, severity of spongiform change, degree of astrocytosis as well as immunohistochemical and molecular patterns of the disease-associated isoform of the prion protein (PrPd) in the caudal brainstem. Our results indicate significantly higher intensities of spongiform change in clinically affected compared to asymptomatic BSE cases. Similar effects were in trend observed for the intensities of PrPd deposition and astrocytosis, whereas the frequencies of morphological PrPd types and the molecular patterns in Western immunoblot were not different. Importantly, none of the animals included in this study revealed features of atypical BSE. Taken together, this study suggests that both clinically affected as well as asymptomatic Swiss BSE cases in cattle share the neuropathological and molecular phenotype of classical BSE and that asymptomatic classical BSE cases are at a pre-clinical stage of the disease rather than representing a true sub-clinical form of BSE.

Item Type:

Journal Article (Original Article)

Division/Institute:

05 Veterinary Medicine > Department of Clinical Veterinary Medicine (DKV) > DVK - Clinical Research (discontinued)
05 Veterinary Medicine > Department of Clinical Research and Veterinary Public Health (DCR-VPH) > Experimental Clinical Research
05 Veterinary Medicine > Department of Clinical Veterinary Medicine (DKV) > DKV - Clinical Neurology

UniBE Contributor:

Siso, Silvia; Doherr, Marcus; Botteron, Catherine; Zurbriggen, Andreas; Vandevelde, Marc and Seuberlich, Torsten

ISSN:

0001-6322

Publisher:

Springer-Verlag

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:52

Last Modified:

26 Jun 2018 13:51

Publisher DOI:

10.1007/s00401-007-0283-9

PubMed ID:

17763857

Web of Science ID:

000249915800006

BORIS DOI:

10.7892/boris.22251

URI:

https://boris.unibe.ch/id/eprint/22251 (FactScience: 33597)

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