Immunohistochemical demonstration of the putative canine distemper virus receptor CD150 in dogs with and without distemper

Wenzlow, N; Plattet, Philippe; Wittek, R; Zurbriggen, Andreas; Gröne, A (2007). Immunohistochemical demonstration of the putative canine distemper virus receptor CD150 in dogs with and without distemper. Veterinary pathology, 44(6), pp. 943-8. Middleton, Wis.: American College of Veterinary Pathologists 10.1354/vp.44-6-943

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Signaling lymphocyte activation molecule (SLAM) or CD150 can function as a receptor for the canine distemper virus (CDV) in vitro. The expression of SLAM was studied using immunohistochemistry in order to evaluate the presence and distribution of the receptor in dogs in vivo. Additionally, receptor expression was assessed after experimental infection of dogs with CDV. In 7 control dogs without distemper virus, the receptor was found in various tissues, mostly on cells morphologically identified as lymphocytes and macrophages. In 7 dogs with early distemper lesions characterized by presence of the virus, higher numbers of SLAM-expressing cells were found in multiple tissues recognized as targets of CDV compared with those in control dogs. These findings suggest that SLAM, a putative distemper receptor, is expressed in dogs in vivo. Additionally, virus infection is associated with up-regulation of SLAM, potentially causing an amplification of virus in the host.

Item Type:

Journal Article (Original Article)

Division/Institute:

05 Veterinary Medicine > Department of Clinical Research and Veterinary Public Health (DCR-VPH) > Experimental Clinical Research
05 Veterinary Medicine > Department of Clinical Research and Veterinary Public Health (DCR-VPH)

UniBE Contributor:

Plattet, Philippe and Zurbriggen, Andreas

ISSN:

0300-9858

Publisher:

American College of Veterinary Pathologists

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:52

Last Modified:

16 Feb 2015 13:35

Publisher DOI:

10.1354/vp.44-6-943

PubMed ID:

18039911

Web of Science ID:

000251020600021

URI:

https://boris.unibe.ch/id/eprint/22261 (FactScience: 33630)

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