The impact of input fluctuations on the frequency-current relationships of layer 5 pyramidal neurons in the rat medial prefrontal cortex

Arsiero, Maura; Lüscher, Hans-Rudolf; Lundstrom, Brian Nils; Giugliano, Michele (2007). The impact of input fluctuations on the frequency-current relationships of layer 5 pyramidal neurons in the rat medial prefrontal cortex. Journal of neuroscience, 27(12), pp. 3274-84. Washington, D.C.: Society for Neuroscience 10.1523/JNEUROSCI.4937-06.2007

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The role of irregular cortical firing in neuronal computation is still debated, and it is unclear how signals carried by fluctuating synaptic potentials are decoded by downstream neurons. We examined in vitro frequency versus current (f-I) relationships of layer 5 (L5) pyramidal cells of the rat medial prefrontal cortex (mPFC) using fluctuating stimuli. Studies in the somatosensory cortex show that L5 neurons become insensitive to input fluctuations as input mean increases and that their f-I response becomes linear. In contrast, our results show that mPFC L5 pyramidal neurons retain an increased sensitivity to input fluctuations, whereas their sensitivity to the input mean diminishes to near zero. This implies that the discharge properties of L5 mPFC neurons are well suited to encode input fluctuations rather than input mean in their firing rates, with important consequences for information processing and stability of persistent activity at the network level.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Physiology

UniBE Contributor:

Arsiero, Maura

ISSN:

0270-6474

ISBN:

17376988

Publisher:

Society for Neuroscience

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:52

Last Modified:

04 May 2014 23:15

Publisher DOI:

10.1523/JNEUROSCI.4937-06.2007

PubMed ID:

17376988

Web of Science ID:

000245103700023

URI:

https://boris.unibe.ch/id/eprint/22267 (FactScience: 33716)

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