A guide to sparkology: the taxonomy of elementary cellular Ca2+ signaling events

Niggli, Ernst; Shirokova, Natalia (2007). A guide to sparkology: the taxonomy of elementary cellular Ca2+ signaling events. Cell calcium, 42(4-5), pp. 379-87. Amsterdam: Elsevier 10.1016/j.ceca.2007.02.010

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Since the discovery of the Ca(2+) spark as an elementary event of cellular Ca(2+) signaling almost 15 years ago, the family of newly described Ca(2+) signal entities has been ever growing. While scientists working in Ca(2+) signaling may have maintained an overview over the specifics of this nomenclature, those outside the field often make the complaint that they feel hopelessly lost. With the present review we collect and summarize systematic information on the many Ca(2+) signaling events described in a variety of tissues and cells, and we emphasize why and how each of them has its own importance. Most of these signals are taking place in the cytosol of the respective cells, but several events have been recorded from intracellular organelles as well, where they may serve their own specific functions. Finally, we also try to convey an integrated view as to why cellular microdomain signaling is of fundamental biological importance.

Item Type:	Journal Article (Original Article)
Division/Institute:	04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Physiology
UniBE Contributor:	Niggli, Ernst
ISSN:	0143-4160
ISBN:	17428535
Publisher:	Elsevier
Language:	English
Submitter:	Factscience Import
Date Deposited:	04 Oct 2013 14:53
Last Modified:	05 Dec 2022 14:16
Publisher DOI:	10.1016/j.ceca.2007.02.010
PubMed ID:	17428535
Web of Science ID:	000249746200005
URI:	https://boris.unibe.ch/id/eprint/22291 (FactScience: 33902)