Urbanczik, R (2007). Enumerating constrained elementary flux vectors of metabolic networks. IET systems biology, 1(5), pp. 274-9. Stevenage, UK: IET 10.1049/iet-syb:20060073
Full text not available from this repository. (Request a copy)The concept of elementary vector is generalised to the case where the steady-state space of the metabolic network is not a flux cone but is a general polyhedron due to further inhomogeneous constraints on the flows through some of the reactions. On one hand, this allows to selectively enumerate elementary modes which satisfy certain optimality criteria and this can yield a large computational gain compared with full enumeration. On the other hand, in contrast to the single optimum found by executing a linear program, this enables a comprehensive description of the set of alternate optima often encountered in flux balance analysis. The concepts are illustrated on a metabolic network model of human cardiac mitochondria.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Physiology |
UniBE Contributor: |
Urbanczik, Robert |
ISSN: |
1751-8849 |
ISBN: |
17907675 |
Publisher: |
IET |
Language: |
English |
Submitter: |
Factscience Import |
Date Deposited: |
04 Oct 2013 14:53 |
Last Modified: |
05 Dec 2022 14:16 |
Publisher DOI: |
10.1049/iet-syb:20060073 |
PubMed ID: |
17907675 |
Web of Science ID: |
000249616500004 |
URI: |
https://boris.unibe.ch/id/eprint/22300 (FactScience: 33924) |
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