Matter, Matthias; Pavelic, Viktor; Pinschewer, Daniel D; Mumprecht, Sabine; Eschli, Bruno; Giroglou, Tsanan; von Laer, Dorothee; Ochsenbein, Adrian F (2007). Decreased tumor surveillance after adoptive T-cell therapy. Cancer research, 67(15), pp. 7467-76. Birmingham, Ala.: American Association for Cancer Research AACR 10.1158/0008-5472.CAN-06-4372
Full text not available from this repository. (Request a copy)The effect of cancer immunotherapy on the endogenous immune response against tumors is largely unknown. Therefore, we studied immune responses against murine tumors expressing the glycoprotein (GP) and/or nucleoprotein of lymphocytic choriomeningitis virus (LCMV) with or without adoptive T-cell therapy. In nontreated animals, CTLs specific for different epitopes as well as LCMV-GP-specific antibodies contributed to tumor surveillance. Adoptive immunotherapy with monoclonal CTLs specific for LCMV-gp33 impaired the endogenous tumor-specific antibody and CTL response by targeting antigen cross-presenting cells. As a consequence and in contrast to expectations, immunotherapy enhanced tumor growth. Thus, for certain immunogenic tumors, a reduction of tumor-specific B- and T-cell responses and enhanced tumor growth may be an unwanted consequence of adoptive immunotherapy.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Clinic of Medical Oncology |
UniBE Contributor: |
Ochsenbein, Adrian |
ISSN: |
0008-5472 |
ISBN: |
17671217 |
Publisher: |
American Association for Cancer Research AACR |
Submitter: |
Factscience Import |
Date Deposited: |
04 Oct 2013 14:53 |
Last Modified: |
05 Dec 2022 14:16 |
Publisher DOI: |
10.1158/0008-5472.CAN-06-4372 |
PubMed ID: |
17671217 |
Web of Science ID: |
000248529300050 |
URI: |
https://boris.unibe.ch/id/eprint/22407 (FactScience: 34543) |
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