Stauffiger, Andrea; Leumann, Christian J. (2007). Synthesis of the bicyclo-[4.3.0]thymidyl nucleoside via Pd(II)-mediated ring expansion chemistry. Nucleosides, nucleotides & nucleic acids, 26(6-7), pp. 615-619. Philadelphia, Pa.: Taylor & Francis 10.1080/15257770701490407
![[img]](https://boris.unibe.ch/style/images/fileicons/text.png) |
Text
NucNucNuc.pdf - Published Version Restricted to registered users only Available under License Publisher holds Copyright. Download (90kB) |
A variety of modified nucleosides to improve antisense oligodeoxynucleotide properties such as target affinity, nuclease resistance, and pharmacokinetics were developed in the last two decades. In the context of conformational restriction we present here the synthesis of the [4.3.0]-bicyclo-DNA thymine monomer via Pd(II)-mediated ring expansion of an intermediate of the tricyclo-DNA synthesis.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
08 Faculty of Science > Department of Chemistry, Biochemistry and Pharmaceutical Sciences (DCBP) |
UniBE Contributor: |
Stauffiger, Andrea, Leumann, Christian |
Subjects: |
500 Science > 570 Life sciences; biology 500 Science > 540 Chemistry |
ISSN: |
1525-7770 |
Publisher: |
Taylor & Francis |
Language: |
English |
Submitter: |
Christian Leumann |
Date Deposited: |
04 Oct 2013 14:53 |
Last Modified: |
05 Dec 2022 14:16 |
Publisher DOI: |
10.1080/15257770701490407 |
Web of Science ID: |
000251875300016 |
BORIS DOI: |
10.7892/boris.22452 |
URI: |
https://boris.unibe.ch/id/eprint/22452 (FactScience: 34748) |
Actions (login required)
 |
Edit item |