Synthesis of the bicyclo-[4.3.0]thymidyl nucleoside via Pd(II)-mediated ring expansion chemistry

Stauffiger, Andrea; Leumann, Christian J. (2007). Synthesis of the bicyclo-[4.3.0]thymidyl nucleoside via Pd(II)-mediated ring expansion chemistry. Nucleosides, nucleotides & nucleic acids, 26(6-7), pp. 615-619. Philadelphia, Pa.: Taylor & Francis 10.1080/15257770701490407

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A variety of modified nucleosides to improve antisense oligodeoxynucleotide properties such as target affinity, nuclease resistance, and pharmacokinetics were developed in the last two decades. In the context of conformational restriction we present here the synthesis of the [4.3.0]-bicyclo-DNA thymine monomer via Pd(II)-mediated ring expansion of an intermediate of the tricyclo-DNA synthesis.

Item Type:

Journal Article (Original Article)

Division/Institute:

08 Faculty of Science > Departement of Chemistry and Biochemistry

UniBE Contributor:

Stauffiger, Andrea and Leumann, Christian

Subjects:

500 Science > 570 Life sciences; biology
500 Science > 540 Chemistry

ISSN:

1525-7770

Publisher:

Taylor & Francis

Language:

English

Submitter:

Christian Leumann

Date Deposited:

04 Oct 2013 14:53

Last Modified:

10 Aug 2015 11:03

Publisher DOI:

10.1080/15257770701490407

Web of Science ID:

000251875300016

BORIS DOI:

10.7892/boris.22452

URI:

https://boris.unibe.ch/id/eprint/22452 (FactScience: 34748)

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