T-cadherin is present on endothelial microparticles and is elevated in plasma in early atherosclerosis

Philippova, Maria; Suter, Yves; Toggweiler, Stefan; Schoenenberger, Andreas W; Joshi, Manjunath B; Kyriakakis, Emmanouil; Erne, Paul; Resink, Thérèse J (2011). T-cadherin is present on endothelial microparticles and is elevated in plasma in early atherosclerosis. European Heart Journal, 32(6), pp. 760-71. Oxford: Oxford University Press 10.1093/eurheartj/ehq206

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The presence of endothelial cell (EC)-derived surface molecules in the circulation is among hallmarks of endothelial activation and damage in vivo. Previous investigations suggest that upregulation of T-cadherin (T-cad) on the surface of ECs may be a characteristic marker of EC activation and stress. We investigated whether T-cad might also be shed from ECs and in amounts reflecting the extent of activation or damage.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of General Internal Medicine (DAIM) > Geriatric Clinic

UniBE Contributor:

Schoenenberger, Andreas

ISSN:

0195-668X

Publisher:

Oxford University Press

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:12

Last Modified:

27 Apr 2018 10:06

Publisher DOI:

10.1093/eurheartj/ehq206

PubMed ID:

20584775

Web of Science ID:

000288549100021

BORIS DOI:

10.7892/boris.2250

URI:

https://boris.unibe.ch/id/eprint/2250 (FactScience: 204622)

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