Rapid induction of remission in large vessel vasculitis by IL-6 blockade. A case series

Seitz, Michael; Reichenbach, Stephan; Bonel, Harald M; Adler, Sabine; Wermelinger, Felix; Villiger, Peter M (2011). Rapid induction of remission in large vessel vasculitis by IL-6 blockade. A case series. Swiss medical weekly, 141, w13156. Muttenz: EMH Schweizerischer Ärzteverlag 10.4414/smw.2011.13156

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OBJECTIVE: To evaluate the effect of IL-6 blockade using tocilizumab in inducing remission of arterial large vessel vasculitides (LVV). METHODS: Five consecutive patients with giant-cell arteritis (GCA) and two with Takayasu’s arteritis (TA) were treated by tocilizumab infusions (8 mg/kg). Tocilizumab was given every other week for the first month and once monthly thereafter. Clinical symptoms of disease activity, erythrocyte sedimentation rate (ESR), C-reactive protein (CRP) level and glucocorticoid (GC) dosage necessary to maintain remission were prospectively assessed. MR angiography was performed to monitor local inflammation. RESULTS: Of the seven patients three were newly diagnosed and four showed GC resistance, i.e. GC could not be lowered to less than 7.5 mg/day. The mean follow-up time was 4.3 months (range 3–7 months). All patients achieved a rapid and complete clinical response and normalisation of the acute phase proteins. Remarkably, prednisone dosage could be reduced within 12 weeks to a mean of 2.5 mg/day (range 0–10 mg/day). No relapse and no drug-related side effects were noted. CONCLUSION: Collectively the data suggest that IL-6 blockade using tocilizumab qualifies as a therapeutic option to induce rapid remission in large vessel vasculitides.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Dermatology, Urology, Rheumatology, Nephrology, Osteoporosis (DURN) > Clinic of Rheumatology, Clinical Immunology and Allergology
04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Social and Preventive Medicine
04 Faculty of Medicine > Department of Radiology, Neuroradiology and Nuclear Medicine (DRNN) > Institute of Diagnostic, Interventional and Paediatric Radiology

UniBE Contributor:

Seitz, Michael; Reichenbach, Stephan; Bonel, Harald Marcel; Adler, Sabine; Wermelinger, Felix and Villiger, Peter

ISSN:

1424-7860

Publisher:

EMH Schweizerischer Ärzteverlag

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:12

Last Modified:

09 Sep 2017 15:07

Publisher DOI:

10.4414/smw.2011.13156

PubMed ID:

21243547

Web of Science ID:

000289992600001

BORIS DOI:

10.7892/boris.2258

URI:

https://boris.unibe.ch/id/eprint/2258 (FactScience: 204643)

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