Willcox, Merlin L; Graz, Bertrand; Falquet, Jacques; Sidibé, Oumar; Forster, Mathieu; Diallo, Drissa (2007). Argemone mexicana decoction for the treatment of uncomplicated falciparum malaria. Transactions of the Royal Society of Tropical Medicine and Hygiene, 101(12), pp. 1190-8. Amsterdam: Royal Society of Tropical Medicine and Hygiene 10.1016/j.trstmh.2007.05.017
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Willcox TransRoyalSocTropicalMedHyg 2007.pdf - Published Version Available under License Publisher holds Copyright. Download (624kB) | Preview |
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A prospective, dose-escalating, quasi-experimental clinical trial was conducted with a traditional healer using a decoction of Argemone mexicana for the treatment of malaria in Mali. The remedy was prescribed in three regimens: once daily for 3 days (Group A; n=23); twice daily for 7 days (Group B; n=40); and four times daily for the first 4 days followed by twice daily for 3 days (Group C; n=17). Thus, 80 patients were included, of whom 80% were aged<5 years and 25% were aged<1 year. All presented to the traditional healer with symptoms of malaria and had a Plasmodium falciparum parasitaemia>2000/microl but no signs of severe malaria. The proportions of adequate clinical response (ACR) at Day 14 were 35%, 73% and 65% in Groups A, B and C, respectively (P=0.011). At Day 14, overall proportions of ACR were lower in children aged<1 year (45%) and higher in patients aged>5 years (81%) (P=0.027). Very few patients had complete parasite clearance, but at Day 14, 67% of patients with ACR had a parasitaemia<2000/microl. No patient needed referral for severe disease. Only minor side effects were observed. Further research should determine whether this local resource could represent a first-aid home treatment in remote areas.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Social and Preventive Medicine (ISPM) |
UniBE Contributor: |
Forster, Mathieu |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
0035-9203 |
ISBN: |
17920092 |
Publisher: |
Royal Society of Tropical Medicine and Hygiene |
Language: |
English |
Submitter: |
Factscience Import |
Date Deposited: |
04 Oct 2013 14:53 |
Last Modified: |
05 Dec 2022 14:16 |
Publisher DOI: |
10.1016/j.trstmh.2007.05.017 |
PubMed ID: |
17920092 |
Web of Science ID: |
000251603300007 |
BORIS DOI: |
10.7892/boris.22642 |
URI: |
https://boris.unibe.ch/id/eprint/22642 (FactScience: 35700) |
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