Wheeze and asthma prevalence and related health-service use in white and south Asian pre-schoolchildren in the United Kingdom

Kuehni, C E; Strippoli, M-P F; Low, N; Brooke, A M; Silverman, M (2007). Wheeze and asthma prevalence and related health-service use in white and south Asian pre-schoolchildren in the United Kingdom. Clinical and experimental allergy, 37(12), pp. 1738-46. Oxford: Blackwell Scientific Publications 10.1111/j.1365-2222.2007.02784.x

[img] Text
Kuehni ClinExpAllergy 2007.pdf - Published Version
Restricted to registered users only
Available under License Publisher holds Copyright.

Download (115kB) | Request a copy

BACKGROUND: Epidemiological data for south Asian children in the United Kingdom are contradictory, showing a lower prevalence of wheeze, but a higher rate of medical consultations and admissions for asthma compared with white children. These studies have not distinguished different asthma phenotypes or controlled for varying environmental exposures. OBJECTIVE: To compare the prevalence of wheeze and related health-service use in south Asian and white pre-schoolchildren in the United Kingdom, taking into account wheeze phenotype (viral and multiple wheeze) and environmental exposures. METHODS: A postal questionnaire was completed by parents of a population-based sample of 4366 white and 1714 south Asian children aged 1-4 years in Leicestershire, UK. Children were classified as having viral wheeze or multiple trigger wheeze. RESULTS: The prevalence of current wheeze was 35.6% in white and 25.5% in south Asian 1-year-olds (P<0.001), and 21.9% and 20.9%, respectively, in children aged 2-4 years. Odds ratios (ORs) (95% confidence interval) for multiple wheeze and for viral wheeze, comparing south Asian with white children, were 2.21 (1.19-4.09) and 1.43 (0.77-2.65) in 2-4-year-olds after controlling for socio-economic conditions, environmental exposures and family history. In 1-year-olds, the respective ORs for multiple and viral wheeze were 0.66 (0.47-0.92) and 0.81 (0.64-1.03). Reported GP consultation rates for wheeze and hospital admissions were greater in south Asian children aged 2-4 years, even after adjustment for severity, but the use of inhaled corticosteroids was lower. CONCLUSIONS: South Asian 2-4-year-olds are more likely than white children to have multiple wheeze (a condition with many features of chronic atopic asthma), after taking into account ethnic differences in exposure to some environmental agents. Undertreatment with inhaled corticosteroids might partly explain their greater use of health services.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Social and Preventive Medicine (ISPM)

UniBE Contributor:

Kühni, Claudia; Strippoli, Marie-Pierre and Low, Nicola

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0954-7894

ISBN:

18028098

Publisher:

Blackwell Scientific Publications

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:53

Last Modified:

11 Dec 2014 09:54

Publisher DOI:

10.1111/j.1365-2222.2007.02784.x

PubMed ID:

18028098

Web of Science ID:

000251048800004

BORIS DOI:

10.7892/boris.22661

URI:

https://boris.unibe.ch/id/eprint/22661 (FactScience: 35750)

Actions (login required)

Edit item Edit item
Provide Feedback