Objective response to radiation therapy and long-term survival of patients with WHO grade II astrocytic gliomas with known LOH 1p/19q status

Fathi, Ali-Reza; Vassella, Erik; Arnold, Marlene; Curschmann, Jürgen; Reinert, Michael; Vajtai, Istvan; Weis, Joachim; Deiana, Gianluca; Mariani, Luigi (2007). Objective response to radiation therapy and long-term survival of patients with WHO grade II astrocytic gliomas with known LOH 1p/19q status. Strahlentherapie und Onkologie, 183(9), pp. 517-22. Heidelberg: Urban & Vogel 10.1007/s00066-007-1673-6

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BACKGROUND: WHO grade II gliomas are often approached by radiation therapy (RT). However, little is known about tumor response and its potential impact on long-term survival. PATIENTS AND METHODS: Patients subjected to RT were selected from the own database of WHO grade II gliomas diagnosed between 1991 and 2000. The volumetric tumor response after RT was assessed based on magnetic resonance imaging and graded according to standard criteria as complete, partial (PR, >or= 50%), or minor (MR, 25% to <50%). RESULTS: There were 24 astrocytomas and three oligoastrocytomas. 21 patients (78%) were dead at follow-up (mean survival 74 months). None of the patients had chemotherapy. Objective response occurred in 14 patients (52%, five PR and nine MR) but was not associated with overall survival. The vast majority of the tumors had no loss of heterozygosity (LOH) 1p and/or 19q (86%). CONCLUSION: Approximately 50% of patients with astrocytic WHO grade II gliomas respond to RT despite the absence of LOH for 1p/19q. The potential predictive factors for response and the impact of response on overall survival remain unclear.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurosurgery
04 Faculty of Medicine > Service Sector > Institute of Pathology

UniBE Contributor:

Fathi, Ali Reza; Vassella, Erik; Arnold, Marlene; Reinert, Michael; Vajtai, Istvan and Mariani, Luigi

ISSN:

0179-7158

ISBN:

17762927

Publisher:

Urban & Vogel

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:53

Last Modified:

26 Jun 2018 14:46

Publisher DOI:

10.1007/s00066-007-1673-6

PubMed ID:

17762927

Web of Science ID:

000249206600008

BORIS DOI:

10.7892/boris.22667

URI:

https://boris.unibe.ch/id/eprint/22667 (FactScience: 35782)

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