Peroxide bond-dependent antiplasmodial specificity of artemisinin and OZ277 (RBx11160)

Kaiser, Marcel; Wittlin, Sergio; Nehrbass-Stuedli, Angela; Dong, Yuxiang; Wang, Xiaofang; Hemphill, Andrew; Matile, Hugues; Brun, Reto; Vennerstrom, Jonathan L (2007). Peroxide bond-dependent antiplasmodial specificity of artemisinin and OZ277 (RBx11160). Antimicrobial agents and chemotherapy, 51(8), pp. 2991-3. Washington, D.C.: American Society for Microbiology 10.1128/AAC.00225-07

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Using nonperoxidic analogs of artemisinin and OZ277 (RBx11160), the strong in vitro antiplasmodial activities of the latter two compounds were shown to be peroxide bond dependent. In contrast, the weak activities of artemisinin and OZ277 against six other protozoan parasites were peroxide bond independent. These data support the iron-dependent artemisinin alkylation hypothesis.

Item Type:

Journal Article (Original Article)

Division/Institute:

05 Veterinary Medicine > Department of Infectious Diseases and Pathobiology (DIP) > Institute of Parasitology

UniBE Contributor:

Hemphill, Andrew

ISSN:

0066-4804

Publisher:

American Society for Microbiology

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:53

Last Modified:

21 Jan 2014 15:05

Publisher DOI:

10.1128/AAC.00225-07

PubMed ID:

17562801

Web of Science ID:

000248523700047

URI:

https://boris.unibe.ch/id/eprint/22732 (FactScience: 36364)

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