Targeting CCK receptors in human cancers

Reubi, Jean Claude (2007). Targeting CCK receptors in human cancers. Current topics in medicinal chemistry, 7(12), pp. 1239-42. Hilversum: Bentham Science Publishers

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Gut hormone receptors can be over-expressed in several human cancers and represent the basis for receptor-targeted tumor imaging and therapy. A promising receptor for such clinical applications is the cholecystokinin receptor. Cholecystokinin receptors are expressed in numerous neuroendocrine tumors, in particular medullary thyroid carcinomas and neuroendocrine gut tumors, as well as in stromal tumors. Moreover, several radiolabeled CCK or gastrin analogs have been developed allowing to detect these tumors and their metastases in patients using in vivo cholecystokinin receptor scintigraphy, proving the feasibility of targeting CCK receptors in human tumors in vivo.

Item Type:

Journal Article (Further Contribution)

Division/Institute:

04 Faculty of Medicine > Service Sector > Institute of Pathology

UniBE Contributor:

Reubi-Kattenbusch, Jean-Claude

Subjects:

500 Science > 570 Life sciences; biology
600 Technology > 610 Medicine & health

ISSN:

1568-0266

ISBN:

17584145

Publisher:

Bentham Science Publishers

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:54

Last Modified:

17 Oct 2019 09:57

PubMed ID:

17584145

Web of Science ID:

000248568500010

URI:

https://boris.unibe.ch/id/eprint/22759 (FactScience: 36471)

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