Thermal model for optimization of vascular laser tissue soldering

Bogni, Serge; Stumpp, Oliver; Reinert, Michael; Frenz, Martin (2010). Thermal model for optimization of vascular laser tissue soldering. Journal of biophotonics, 3(5-6), pp. 284-95. Weinheim: Wiley-VCH 10.1002/jbio.201000009

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Laser tissue soldering (LTS) is a promising technique for tissue fusion based on a heat-denaturation process of proteins. Thermal damage of the fused tissue during the laser procedure has always been an important and challenging problem. Particularly in LTS of arterial blood vessels strong heating of the endothelium should be avoided to minimize the risk of thrombosis. A precise knowledge of the temperature distribution within the vessel wall during laser irradiation is inevitable. The authors developed a finite element model (FEM) to simulate the temperature distribution within blood vessels during LTS. Temperature measurements were used to verify and calibrate the model. Different parameters such as laser power, solder absorption coefficient, thickness of the solder layer, cooling of the vessel and continuous vs. pulsed energy deposition were tested to elucidate their impact on the temperature distribution within the soldering joint in order to reduce the amount of further animal experiments. A pulsed irradiation with high laser power and high absorbing solder yields the best results.

Item Type:

Journal Article (Original Article)

Division/Institute:

08 Faculty of Science > Institute of Applied Physics
04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurosurgery

UniBE Contributor:

Bogni, Serge; Stumpp, Oliver; Reinert, Michael and Frenz, Martin

ISSN:

1864-063X

Publisher:

Wiley-VCH

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:12

Last Modified:

06 Dec 2013 13:22

Publisher DOI:

10.1002/jbio.201000009

PubMed ID:

20196032

Web of Science ID:

000278886700005

URI:

https://boris.unibe.ch/id/eprint/2281 (FactScience: 204676)

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