Hepatocellular carcinoma, syncytial giant cell: a novel variant in children: a case report

Atra, A; Al-Asiri, R; Wali, S; Al-Husseini, H; Al-Bassas, A; Zimmermann, A (2007). Hepatocellular carcinoma, syncytial giant cell: a novel variant in children: a case report. Annals of diagnostic pathology, 11(1), pp. 61-3. New York, N.Y.: Elsevier 10.1016/j.anndiagpath.2005.12.005

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Hepatocellular carcinoma (HCC) is the second most common primary malignant hepatic tumor in children. It often develops in patients with underlying liver disease. We report the clinicopathologic features of an unusual HCC occurring in an infant who presented with features of Cushing's syndrome due to bilateral adrenal hyperplasia. The tumor is characterized by epithelial syncytial giant cells. Giant cell carcinoma of the liver has been previously reported, but the cells were osteoclast-like (ie, mesenchymal type) and not epithelial type as it is in this patient. We propose to use the term HCC, syncytial giant cell type, to denote this apparently novel lesion.

Item Type:

Journal Article (Further Contribution)

Division/Institute:

04 Faculty of Medicine > Service Sector > Institute of Pathology

UniBE Contributor:

Zimmermann, Arthur

ISSN:

1092-9134

ISBN:

17240310

Publisher:

Elsevier

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:54

Last Modified:

04 May 2014 23:15

Publisher DOI:

10.1016/j.anndiagpath.2005.12.005

PubMed ID:

17240310

Web of Science ID:

000248870200011

URI:

https://boris.unibe.ch/id/eprint/22838 (FactScience: 37257)

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