Cerebellar cortical degeneration with selective granule cell loss in Bavarian mountain dogs

Flegel, T; Matiasek, K; Henke, D; Grevel, V (2007). Cerebellar cortical degeneration with selective granule cell loss in Bavarian mountain dogs. Journal of small animal practice, 48(8), pp. 462-5. Oxford: Pergamon Press 10.1111/j.1748-5827.2006.00257.x

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Three Bavarian mountain dogs aged between 18 and 20 months, not related to each other, were presented with chronic signs of cerebellar dysfunction. On sagittal T2-weighted magnetic resonance imaging brain images, the tentative diagnosis of cerebellar hypoplasia was established based on an enlarged cerebrospinal fluid space around the cerebellum and an increased cerebrospinal fluid signal between the folia. Post-mortem examination was performed in one dog and did show an overall reduction of cerebellar size. On histopathologic examination, a selective loss of cerebellar granule cells with sparing of Purkinje cells was evident. Therefore, the Bavarian mountain dog is a breed where cerebellar cortical degeneration caused by the rather exceptional selective granule cell loss can be seen as cause of chronic, slowly progressive cerebellar dysfunction starting at an age of several months.

Item Type:

Journal Article (Original Article)


05 Veterinary Medicine > Department of Clinical Veterinary Medicine (DKV) > DKV - Clinical Neurology

UniBE Contributor:

Henke, Diana




Pergamon Press




Factscience Import

Date Deposited:

04 Oct 2013 14:54

Last Modified:

21 Jan 2014 15:05

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PubMed ID:


Web of Science ID:



https://boris.unibe.ch/id/eprint/22866 (FactScience: 37381)

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