Short telomeres and high telomerase activity in T-cell prolymphocytic leukemia

Röth, A; Dürig, J; Himmelreich, H; Bug, S; Siebert, R; Dührsen, U; Lansdorp, P M; Baerlocher, G M (2007). Short telomeres and high telomerase activity in T-cell prolymphocytic leukemia. Leukemia, 21(12), pp. 2456-62. Basingstoke: Nature Publishing Group 10.1038/sj.leu.2404968

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To test the role of telomere biology in T-cell prolymphocytic leukemia (T-PLL), a rare aggressive disease characterized by the expansion of a T-cell clone derived from immuno-competent post-thymic T-lymphocytes, we analyzed telomere length and telomerase activity in subsets of peripheral blood leukocytes from 11 newly diagnosed or relapsed patients with sporadic T-PLL. Telomere length values of the leukemic T cells (mean+/-s.d.: 1.53+/-0.65 kb) were all below the 1st percentile of telomere length values observed in T cells from healthy age-matched controls whereas telomere length of normal T- and B cells fell between the 1st and 99th percentile of the normal distribution. Leukemic T cells exhibited high levels of telomerase and were sensitive to the telomerase inhibitor BIBR1532 at doses that showed no effect on normal, unstimulated T cells. Targeting the short telomeres and telomerase activity in T-PLL seems an attractive strategy for the future treatment of this devastating disease.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Clinic of Haematology and Central Haematological Laboratory

UniBE Contributor:

Baerlocher, Gabriela M.

ISSN:

0887-6924

ISBN:

17898784

Publisher:

Nature Publishing Group

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:54

Last Modified:

04 May 2014 23:15

Publisher DOI:

10.1038/sj.leu.2404968

PubMed ID:

17898784

Web of Science ID:

000251139500009

URI:

https://boris.unibe.ch/id/eprint/22895 (FactScience: 37609)

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