[Pancytopenia and hemolysis--diagnosis, differential diagnosis and therapy of pernicious anemia]

Meier, N; Lipp, E; Solenthaler, M (2007). [Pancytopenia and hemolysis--diagnosis, differential diagnosis and therapy of pernicious anemia]. Deutsche medizinische Wochenschrift, 132(27), pp. 1469-74. Stuttgart: Thieme 10.1055/s-2007-982055

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Pernicious anemia and Vitamin B12 deficiency have a wide range of symptoms and are a common finding in the elderly. A 73 year old female is admitted to the hospital because of dyspnea, fatigue and loss of appetite and weight. While previous medical history and physical examination are inconspicuous, laboratory findings show severe pancytopenia with macrocytosis, low reticulocyte count and marked signs of hemolysis. A very low serum level of vitamin B12 and chronic atrophic type A gastritis upon endoscopy with presence of parietal cell antibodies in the serum lead to the diagnosis of pernicious anemia. Complete restitution is achieved by parenteral vitamin B12 substitution. Nowadays, severe pernicious anemia is only rarely seen. The differential diagnosis of pancytopenia (with macrocytic anemia) combined with hemolysis and the essential hints to the diagnosis of pernicious anemia are discussed, and thereby practical aspects including therapy actualized.

Item Type:

Journal Article (Further Contribution)

Division/Institute:

04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurology
04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Clinic of Haematology and Central Haematological Laboratory

UniBE Contributor:

Meier, Niklaus and Solenthaler, Max

ISSN:

0012-0472

ISBN:

17583831

Publisher:

Thieme

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:54

Last Modified:

04 May 2014 23:15

Publisher DOI:

10.1055/s-2007-982055

PubMed ID:

17583831

Web of Science ID:

000248182500007

URI:

https://boris.unibe.ch/id/eprint/22909 (FactScience: 37638)

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