Impact of variation in acute virulence of BVDV1 strains on design of better vaccine efficacy challenge models

Ridpath, Julia F; Neill, John D; Peterhans, Ernst (2007). Impact of variation in acute virulence of BVDV1 strains on design of better vaccine efficacy challenge models. Vaccine, 25(47), pp. 8058-66. Amsterdam: Elsevier 10.1016/j.vaccine.2007.09.014

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Due to antigenic differences between BVDV1 and BVDV2 strains, both pestivirus species are included in U.S. vaccines. The efficacy of these vaccines in preventing acute infections is evaluated based on reduction of clinical disease. While high virulence BVDV2 strains are used in U.S. vaccine efficacy studies, the BVDV1 strain used (NY-1) produces very little in the way of clinical disease. In order to identify a BVDV1 strain that generates a more pronounced clinical presentation, three field strains were compared to NY-1. Infection with two of the field strains resulted in significantly more pronounced clinical disease compared to NY-1. Decreasing the inoculation of a field strain by two logs did not significantly change clinical presentation.

Item Type:

Journal Article (Original Article)

Division/Institute:

05 Veterinary Medicine > Department of Infectious Diseases and Pathobiology (DIP) > Institute of Virology and Immunology

UniBE Contributor:

Peterhans, Ernst

ISSN:

0264-410X

Publisher:

Elsevier

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:54

Last Modified:

21 Jan 2014 15:05

Publisher DOI:

10.1016/j.vaccine.2007.09.014

PubMed ID:

17942196

Web of Science ID:

000251331400009

URI:

https://boris.unibe.ch/id/eprint/22939 (FactScience: 37871)

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