Molecular mechanisms of alcohol-mediated carcinogenesis

Seitz, Helmut K; Stickel, Felix (2007). Molecular mechanisms of alcohol-mediated carcinogenesis. Nature reviews - cancer, 7(8), pp. 599-612. London: Nature Publishing Group 10.1038/nrc2191

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Approximately 3.6% of cancers worldwide derive from chronic alcohol drinking, including those of the upper aerodigestive tract, the liver, the colorectum and the breast. Although the mechanisms for alcohol-associated carcinogenesis are not completely understood, most recent research has focused on acetaldehyde, the first and most toxic ethanol metabolite, as a cancer-causing agent. Ethanol may also stimulate carcinogenesis by inhibiting DNA methylation and by interacting with retinoid metabolism. Alcohol-related carcinogenesis may interact with other factors such as smoking, diet and comorbidities, and depends on genetic susceptibility.

Item Type:

Journal Article (Further Contribution)

Division/Institute:

04 Faculty of Medicine > Department of Gastro-intestinal, Liver and Lung Disorders (DMLL) > Clinic of Visceral Surgery and Medicine > Hepatology

UniBE Contributor:

Stickel, Felix

ISSN:

1474-175X

ISBN:

17646865

Publisher:

Nature Publishing Group

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:54

Last Modified:

10 Jul 2020 15:41

Publisher DOI:

10.1038/nrc2191

PubMed ID:

17646865

Web of Science ID:

000248394000013

URI:

https://boris.unibe.ch/id/eprint/22962 (FactScience: 38069)

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