Seitz, Helmut K; Stickel, Felix (2007). Molecular mechanisms of alcohol-mediated carcinogenesis. Nature reviews - cancer, 7(8), pp. 599-612. London: Nature Publishing Group 10.1038/nrc2191
Full text not available from this repository. (Request a copy)Approximately 3.6% of cancers worldwide derive from chronic alcohol drinking, including those of the upper aerodigestive tract, the liver, the colorectum and the breast. Although the mechanisms for alcohol-associated carcinogenesis are not completely understood, most recent research has focused on acetaldehyde, the first and most toxic ethanol metabolite, as a cancer-causing agent. Ethanol may also stimulate carcinogenesis by inhibiting DNA methylation and by interacting with retinoid metabolism. Alcohol-related carcinogenesis may interact with other factors such as smoking, diet and comorbidities, and depends on genetic susceptibility.
Item Type: |
Journal Article (Further Contribution) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Department of Gastro-intestinal, Liver and Lung Disorders (DMLL) > Clinic of Visceral Surgery and Medicine > Hepatology |
UniBE Contributor: |
Stickel, Felix |
ISSN: |
1474-175X |
ISBN: |
17646865 |
Publisher: |
Nature Publishing Group |
Language: |
English |
Submitter: |
Factscience Import |
Date Deposited: |
04 Oct 2013 14:54 |
Last Modified: |
05 Dec 2022 14:16 |
Publisher DOI: |
10.1038/nrc2191 |
PubMed ID: |
17646865 |
Web of Science ID: |
000248394000013 |
URI: |
https://boris.unibe.ch/id/eprint/22962 (FactScience: 38069) |
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