Kruse, Anja E; Eisenberger, Ute; Frey, Felix J; Mohaupt, Markus G (2007). Effect of cinacalcet cessation in renal transplant recipients with persistent hyperparathyroidism. Nephrology, dialysis, transplantation, 22(8), pp. 2362-5. Oxford: Oxford University Press 10.1093/ndt/gfm270
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BACKGROUND: Persistent hyperparathyroidism after renal transplantation affects bone and allografts. Cinacalcet, a calcimimetic, reduces serum calcium and PTH in renal transplant recipients with persistent hyperparathyroidism. Here, we address the question whether this effect of cinacalcet persists after withdrawal. METHODS: Therefore, cinacalcet was stopped after 12 months treatment in 10 stable renal transplant patients. Serum calcium, phosphate, PTH, creatinine and cystatin C were monitored for 3 months. RESULTS: Serum calcium, normalized in nine patients before cessation of cinacalcet (2.32 +/- 0.05mmol/l, mean +/- SEM), increased after 3 months of discontinuation by 0.17 +/- 0.04mmol/l, P < 0.05, but remained within the normal range in eight patients. Compared with the time point of cessation, PTH remained unchanged or decreased further after 3 months without therapy in six patients. Measurements of cystatin C suggested an improvement of the glomerular filtration rate after cessation in 9 out of 10 patients (1.55 +/- 0.09 vs 1.33 +/- 0.12 mg/l, P < 0.01). CONCLUSION: First, a beneficial effect of cinacalcet beyond the duration of a 12-month therapy appears to be present in some patients and second, the previously suspected influence of cinacalcet therapy on renal function is reversible. Thus, it is reasonable to consider a trial of cinacalcet cessation to identify these patients. The optimal time point for such a discontinuation is unknown. The present observations are preliminary. They clearly require a prospective randomized trial for definitive confirmation.
Item Type: |
Journal Article (Original Article) |
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Division/Institute: |
04 Faculty of Medicine > Department of Dermatology, Urology, Rheumatology, Nephrology, Osteoporosis (DURN) > Clinic of Nephrology and Hypertension |
UniBE Contributor: |
Kruse, Anja, Eisenberger, Ute, Frey, Felix (B), Mohaupt, Markus |
ISSN: |
0931-0509 |
ISBN: |
17510094 |
Publisher: |
Oxford University Press |
Language: |
English |
Submitter: |
Markus Georg Mohaupt |
Date Deposited: |
04 Oct 2013 14:54 |
Last Modified: |
29 Mar 2023 23:32 |
Publisher DOI: |
10.1093/ndt/gfm270 |
PubMed ID: |
17510094 |
Web of Science ID: |
000249243500041 |
BORIS DOI: |
10.7892/boris.23001 |
URI: |
https://boris.unibe.ch/id/eprint/23001 (FactScience: 38527) |
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