Effect of tenofovir on renal glomerular and tubular function

Fux, Christoph A; Christen, Anna; Zgraggen, Susanne; Mohaupt, Markus G; Furrer, Hansjakob (2007). Effect of tenofovir on renal glomerular and tubular function. AIDS, 21(11), pp. 1483-5. Hagerstown, Md.: Lippincott Williams & Wilkins 10.1097/QAD.0b013e328216f15b

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To evaluate tenofovir-related nephropathy, we quantified calculated glomerular filtration rates (GFR) and renal tubular function in 46 tenofovir-treated patients and 25 without tenofovir. We also analysed patients who stopped tenofovir for drug-related nephrotoxicity at our clinic. Tenofovir use combined with non-nucleoside reverse transcriptase inhibitors, but not with protease inhibitors, resulted in a significant increase in calculated GFR. Tenofovir use was associated with significantly lower phosphatemia and a marginally increased fractional excretion of uric acid, but no other signs of tubulopathy.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Clinic of Infectiology
04 Faculty of Medicine > Department of Dermatology, Urology, Rheumatology, Nephrology, Osteoporosis (DURN) > Clinic of Nephrology and Hypertension

UniBE Contributor:

Fux, Christoph Andreas; Mohaupt, Markus and Furrer, Hansjakob

ISSN:

0269-9370

ISBN:

17589197

Publisher:

Lippincott Williams & Wilkins

Language:

English

Submitter:

Markus Georg Mohaupt

Date Deposited:

04 Oct 2013 14:54

Last Modified:

04 May 2014 23:15

Publisher DOI:

10.1097/QAD.0b013e328216f15b

PubMed ID:

17589197

Web of Science ID:

000248093600014

URI:

https://boris.unibe.ch/id/eprint/23026 (FactScience: 38650)

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